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The first part of this work reports the preparation of some a,ß- unsaturated carbonyl compounds which are useful as starting materials to produce new different types of heterocyclic compounds. In this part of study, we report the relation of 2-acetyl-naphthalene with some aldehydes to give the corresponding a,ß- unsaturated carbonyl compounds (Ia-c). The condensation of these compounds with some carbon and/or nitrogen nucleophiles gave the appropriate pyridine, pyrazole, oxazole derivatives. Biological activity for the synthesized compounds have been studied for anticancer evaluation, and antimicrobial activity.
- Autorenportrait
Doctor of Organic Chemistry,Faculty of Science and Arts,Aljouf University,Qurayyat, Kingdom of Saudi Arabia.Researcher of Organic Chemistry,Photo Chemistry Division,National Research Center,Dokki, Giza, Egypt.
The first part of this work reports the preparation of some a,ß- unsaturated carbonyl compounds which are useful as starting materials to produce new different types of heterocyclic compounds. In this part of study, we report the relation of 2-acetyl-naphthalene with some aldehydes to give the corresponding a,ß- unsaturated carbonyl compounds (Ia-c). The condensation of these compounds with some carbon and/or nitrogen nucleophiles gave the appropriate pyridine, pyrazole, oxazole derivatives. Biological activity for the synthesized compounds have been studied for anticancer evaluation, and antimicrobial activity.
