Roberto Scatena/Patrizia Bottoni/Bruno Giardina: Advances in Mitochondrial Medicine (gebundenes Buch)

InhaltsangabeSection I - Physiology and structure of Mitochondria.- 1.               The oxidative phosphorylation system in mammalian mitochondria.- 2. Physiology and pathophysiology of mitochondrial DNA.- 3. Mitochondrial calcium as a key regulator of mitochondrial activities.- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology.- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology?.- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects.- 7. The mitochondrial pathways of apoptosis.- Section II - Mitochondria and disease.- 8. Inherited mitochondrial disorders.- 9. Mitochondria and metabolism diseases.- 10. Mitochondria and diabetes. An intriguing pathogenetic role.- 11. Mitochondria and heart diseases.- 12. Mitochondria in neurodegeneration.- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation.- Section III - Mitochondria and Aging.- 14.Mitochondria and aging.- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors.- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms.- 18. Anthracyclines and mitochondria.- Section IV-  Applications of Mitochondrial science.- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer.- 20. Mitochondria in Anthropology and forensic medicine.  

This book discusses the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses. It examines mitochondria as a valuable target for xenobiotics and its etiopathogenic role in diseases.

InhaltsangabeSection I - Physiology and structure of Mitochondria.- 1.               The oxidative phosphorylation system in mammalian mitochondria.- 2. Physiology and pathophysiology of mitochondrial DNA.- 3. Mitochondrial calcium as a key regulator of mitochondrial activities.- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology.- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology?.- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects.- 7. The mitochondrial pathways of apoptosis.- Section II - Mitochondria and disease.- 8. Inherited mitochondrial disorders.- 9. Mitochondria and metabolism diseases.- 10. Mitochondria and diabetes. An intriguing pathogenetic role.- 11. Mitochondria and heart diseases.- 12. Mitochondria in neurodegeneration.- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation.- Section III - Mitochondria and Aging.- 14.Mitochondria and aging.- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors.- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms.- 18. Anthracyclines and mitochondria.- Section IV-  Applications of Mitochondrial science.- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer.- 20. Mitochondria in Anthropology and forensic medicine.